CDC42EP3

Across TCGA patient cohorts, CDC42EP3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC42EP3-associated genes across cancer lineages are PKC-delta_pS664, ATM, and 14-3-3_beta. Each is linked with CDC42EP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC42EP3-to-partner and partner-to-CDC42EP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by CDC42EP3-low versus CDC42EP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42EP3→partner) and Y-score (partner→CDC42EP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.097	-1.874	.024	.049	3	2
UCEC	ATM →	-0.773	-2.807	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.105	-2.673	.003	.005	3	1
UCEC	eIF4E →	+0.198	+2.807	.008	<.001	3	1
UCEC	eIF4G →	+0.320	+3.584	.004	.002	3	1
UCEC	FoxM1 →	+0.267	+2.710	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PKC-delta_pS664 by CDC42EP3 expression — UCEC

Explore this box plot interactively →