CDC42EP1

Across TCGA pan-cancer cohorts, CDC42EP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CDC42EP1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CDC42EP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDC42EP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

LSCC, COAD, and GBM are the cancer types where CDC42EP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.824	1.000	.002	34	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	6	view →
GBM	DFS	Quartile	All	0.199	0.503	.014	5	view →
HNSC	OS	Quartile	III,IV	1.000	0.418	.036	4	view →
CCRCC	DFS	Tertile	III,IV	0.714	0.312	.029	2	view →
LUAD	OS	Quartile	II,III,IV	0.750	0.290	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CDC42EP1–LSCC (DFS)

Open the LSCC breakdown →