CDC42EP1

Across TCGA patient cohorts, CDC42EP1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC42EP1-associated genes across cancer lineages are EGFR_pY1068, FOXO3a, and Ku80. Each is linked with CDC42EP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC42EP1-to-partner and partner-to-CDC42EP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CDC42EP1-low versus CDC42EP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42EP1→partner) and Y-score (partner→CDC42EP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.253	-3.000	.037	.036	3	1
UCEC	FOXO3a →	-0.103	-3.140	.036	.019	3	1
UCEC	Ku80 →	+0.312	+2.472	.006	.011	3	1
UCEC	Notch1 →	+0.150	+2.459	.027	.020	3	1
UCEC	p62 Lck ligand →	+0.454	+2.999	.003	.035	3	1
UCEC	Rab25 →	-0.465	-2.459	.003	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by CDC42EP1 expression — UCEC

Explore this box plot interactively →