CDC42EP1

Across TCGA cell cohorts, CDC42EP1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC42EP1-associated genes across cancer lineages are MAGEB5, FABP9, and C16orf90. Each is linked with CDC42EP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC42EP1-to-partner and partner-to-CDC42EP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by CDC42EP1-low versus CDC42EP1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42EP1→partner) and Y-score (partner→CDC42EP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	FABP9 →	+0.093	+4.643	<.001	.008	3	1
SKIN	C16orf90 →	+0.036	+4.467	<.001	.004	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TBR1 →	+0.051	+3.748	<.001	.001	3	1
LARGE_INTESTINE	THUMPD2 →	+0.652	+3.192	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MAGEB5 by CDC42EP1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →