CDC42EP1

Across TCGA cell cohorts, CDC42EP1 mutation is significantly associated with the mutation status of many other genes, with 2,913 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC42EP1-associated genes across cancer lineages are BRPF3, HIVEP1, and MZF1. Each is linked with CDC42EP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDC42EP1-to-partner and partner-to-CDC42EP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRPF3 grouped by CDC42EP1-low versus CDC42EP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42EP1→partner) and Y-score (partner→CDC42EP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BRPF3 →	+2.807	+2.678	.006	.006	1	4
SKIN	HIVEP1 →	+2.830	+3.548	.009	.009	1	3
LARGE_INTESTINE	MZF1 →	+3.544	+3.321	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	POLRMT →	+4.392	+4.954	.008	.008	1	3
OVARY	ATP1A3 →	+4.415	+4.977	.007	.007	1	3
UPPER_AERODIGESTIVE_TRACT	MAP4 →	+4.392	+4.954	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,913 associations by consensus.

BRPF3 by CDC42EP1 expression — LARGE_INTESTINE

Explore this box plot interactively →