CDC42BPG

Across TCGA pan-cancer cohorts, CDC42BPG Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated CDC42BPG data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CDC42BPG Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CDC42BPG expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

THYM, DLBC, and SCLC are the cancer types where CDC42BPG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	27	view →
SCLC	OS	Median	II,III,IV	0.082	0.702	<.001	27	view →
HNSC	OS	Median	III,IV	0.224	0.632	<.001	24	view →
STAD	OS	Median	All	0.147	0.558	.011	16	view →
LIHC	DFS	Median	All	0.094	0.555	.005	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	All	0.847	0.328	.047	4	view →
LUSC	OS	Median	All	0.462	0.679	.035	3	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

CDC42BPG–THYM (OS)

Open the THYM breakdown →