Across TCGA pan-cancer cohorts, CDC42BPB Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CDC42BPB data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CDC42BPB Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CDC42BPB expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.
UCEC, OV, and SCLC are the cancer types where CDC42BPB Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.