CDC42BPA

Across TCGA patient cohorts, CDC42BPA mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC42BPA-associated genes across cancer lineages are ATM, p21, and 14-3-3_beta. Each is linked with CDC42BPA in more than 3 cancer types. Because this analysis shows association rather than direction, both CDC42BPA-to-partner and partner-to-CDC42BPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CDC42BPA-low versus CDC42BPA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42BPA→partner) and Y-score (partner→CDC42BPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.402	-3.000	.008	.034	3	4
UCEC	p21 →	+0.121	+1.099	.021	.016	3	4
COAD	14-3-3_beta →	-0.173	-3.305	.031	.009	3	3
COAD	PDK1 →	-0.149	-3.898	<.001	<.001	3	3
UCEC	P-Cadherin →	-0.085	-1.999	.030	.008	3	3
UCEC	PCNA →	+0.193	+1.473	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

ATM by CDC42BPA expression — COAD

Explore this box plot interactively →