CDC40

Across TCGA pan-cancer cohorts, CDC40 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CDC40 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CDC40 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CDC40 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, BLCA, and UCEC are the cancer types where CDC40 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	OS	Median	All	0.063	0.688	<.001	30	view →
UCEC	DFS	Median	II,III,IV	1.000	0.438	.015	18	view →
UVM	DFS	Median	All	0.141	0.745	.011	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
SARC	DFS	Median	All	0.179	0.612	.024	6	view →
BRCA	DFS	Median	II,III,IV	0.585	0.889	.002	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CDC40–THYM (OS)

Open the THYM breakdown →