CDC40

Across TCGA pan-cancer cohorts, CDC40 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CDC40 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDC40 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDC40 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, GBM, and LSCC are the cancer types where CDC40 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.714	0.927	.005	24	view →
GBM	OS	Tertile	All	0.575	0.167	.002	22	view →
LSCC	DFS	Tertile	All	0.877	0.633	.011	15	view →
LUAD	DFS	Quartile	All	0.865	0.371	.007	9	view →
PDAC	DFS	Tertile	III,IV	0.365	0.635	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CDC40–HNSC (DFS)

Open the HNSC breakdown →