CDC40

Across TCGA patient cohorts, CDC40 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC40-associated genes across cancer lineages are MSH6, eIF4E, and FASN. Each is linked with CDC40 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC40-to-partner and partner-to-CDC40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by CDC40-low versus CDC40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC40→partner) and Y-score (partner→CDC40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.390	-2.459	.001	.018	3	2
UCEC	eIF4E →	+0.197	+3.183	.011	.009	3	1
UCEC	FASN →	+0.289	+1.847	.046	.008	3	1
UCEC	GATA6 →	-0.119	-2.307	.040	.033	3	1
UCEC	JNK2 →	+0.238	+1.594	.001	.021	3	1
UCEC	MEK1 →	+0.372	+3.321	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MSH6 by CDC40 expression — UCEC

Explore this box plot interactively →