CDC40

Across TCGA cell cohorts, CDC40 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,190 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CDC40-associated GO terms across cancer lineages are 7-methylguanosine mRNA capping, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process, and 7-methylguanosine RNA capping. Each is linked with CDC40 in more than 17 cancer types. Because this analysis shows association rather than direction, both CDC40-to-partner and partner-to-CDC40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 7-methylguanosine mRNA capping grouped by CDC40-low versus CDC40-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC40→partner) and Y-score (partner→CDC40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	7-methylguanosine mRNA capping →	+0.115	+0.853	<.001	<.001	3	18
LUNG_SCLC	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.169	+0.888	<.001	<.001	3	18
SKIN	7-methylguanosine RNA capping →	+0.115	+0.853	<.001	<.001	3	18
BLOOD_Myeloma	DNA-templated DNA replication →	+0.094	+0.635	.002	.008	3	15
BLOOD_Myeloma	Spermine biosynthetic process →	+0.146	+0.747	.002	.005	3	15
OVARY	Spermidine biosynthetic process →	+0.127	+0.707	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,190 associations by consensus.

7-methylguanosine mRNA capping by CDC40 expression — SKIN

Explore this box plot interactively →