CDC40

Across TCGA cell cohorts, CDC40 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CDC40-associated genes across cancer lineages are SCGB1D1, PRAMEF10, and PRAMEF17. Each is linked with CDC40 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC40-to-partner and partner-to-CDC40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1D1 grouped by CDC40-low versus CDC40-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC40→partner) and Y-score (partner→CDC40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SCGB1D1 →	+2.546	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	INS →	+0.628	+5.169	<.001	<.001	3	1
BLOOD_Lymphoma	SPATS1 →	+0.789	+4.714	<.001	.002	3	1
SKIN	OXT →	+0.063	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SCGB1D1 by CDC40 expression — LUNG_SCLC

Explore this box plot interactively →