CDC37L1

Across TCGA pan-cancer cohorts, CDC37L1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CDC37L1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CDC37L1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CDC37L1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where CDC37L1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDC37L1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−0.520	<.001	11	view →
LUAD	Male	II,III,IV	+0.231	<.001	6	view →
LSCC	All	All	+0.142	<.001	5	view →
COAD	All	All	+0.135	.025	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CDC37L1–CCRCC

Open the CCRCC breakdown →