CDC37L1

Across TCGA patient cohorts, CDC37L1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC37L1-associated genes across cancer lineages are MEK1, Notch1, and PDCD4. Each is linked with CDC37L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC37L1-to-partner and partner-to-CDC37L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CDC37L1-low versus CDC37L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC37L1→partner) and Y-score (partner→CDC37L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.595	+3.700	<.001	.001	3	1
UCEC	Notch1 →	+0.170	+2.179	.009	.034	3	1
UCEC	PDCD4 →	-0.761	-3.169	<.001	.018	3	1
UCEC	PR →	-0.237	-3.000	.043	.036	3	1
UCEC	Rab25 →	-0.514	-2.584	<.001	.011	3	1
UCEC	TFRC →	+0.563	+2.584	.022	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MEK1 by CDC37L1 expression — UCEC

Explore this box plot interactively →