CDC37

Across TCGA cell cohorts, CDC37 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,722 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CDC37-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of anaphase-promoting complex-dependent catabolic process, and snRNA transcription by RNA polymerase III. Each is linked with CDC37 in more than 13 cancer types. Because this analysis shows association rather than direction, both CDC37-to-partner and partner-to-CDC37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by CDC37-low versus CDC37-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC37→partner) and Y-score (partner→CDC37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.118	+0.709	.005	.001	3	14
SKIN	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.150	+0.985	<.001	<.001	3	13
BONE	snRNA transcription by RNA polymerase III →	+0.081	+0.671	<.001	<.001	3	13
SKIN	Maturation of 5.8S rRNA →	+0.112	+0.914	<.001	<.001	3	13
SKIN	Protein depolymerization →	+0.130	+1.092	<.001	<.001	3	13
BLOOD_Lymphoma	Transcription initiation at RNA polymerase I promoter →	+0.121	+0.781	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,722 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by CDC37 expression — BONE

Explore this box plot interactively →