CDC37

Across TCGA cell cohorts, CDC37 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDC37-associated genes across cancer lineages are GH2, CCDC105, and OR9Q1. Each is linked with CDC37 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC37-to-partner and partner-to-CDC37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GH2 grouped by CDC37-low versus CDC37-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC37→partner) and Y-score (partner→CDC37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GH2 →	+0.030	+5.781	<.001	.001	3	1
BREAST	CCDC105 →	+0.006	+5.169	<.001	.005	3	1
BREAST	OR9Q1 →	+0.013	+5.169	<.001	.005	3	1
BLOOD_Leukemia	PAX1 →	+0.024	+3.475	.001	.006	3	1
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	1
BLOOD_Leukemia	GSC →	+1.468	+3.948	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

GH2 by CDC37 expression — BREAST

Explore this box plot interactively →