CDC37

Across TCGA cell cohorts, CDC37 mutation is significantly associated with the mutation status of many other genes, with 3,430 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDC37-associated genes across cancer lineages are DNM2, HTT, and PRPF31. Each is linked with CDC37 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDC37-to-partner and partner-to-CDC37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNM2 grouped by CDC37-low versus CDC37-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC37→partner) and Y-score (partner→CDC37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DNM2 →	+4.614	+4.614	.006	.006	1	4
BLOOD_Leukemia	HTT →	+2.440	+3.364	<.001	<.001	1	4
BLOOD_Lymphoma	PRPF31 →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	ARRDC2 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	HSD17B1 →	+4.429	+5.247	.005	.005	1	3
BLOOD_Lymphoma	GLS →	+6.014	+6.014	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,430 associations by consensus.

DNM2 by CDC37 expression — CNS

Explore this box plot interactively →