CDC27

Across TCGA pan-cancer cohorts, CDC27 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CDC27 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDC27 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDC27 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where CDC27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.185	0.810	.008	27	view →
PDAC	OS	Quartile	All	0.386	0.660	.022	9	view →
CCRCC	DFS	Quartile	II,III,IV	0.826	0.410	.007	9	view →
UCEC	OS	Median	All	0.983	0.847	.009	8	view →
LUAD	DFS	Tertile	III,IV	0.724	0.328	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CDC27–HNSC (DFS)

Open the HNSC breakdown →