CDC27

Across TCGA patient cohorts, CDC27 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC27-associated genes across cancer lineages are EGFR_pY1173, Myosin-IIa_pS1943, and S6_pS240_S244. Each is linked with CDC27 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC27-to-partner and partner-to-CDC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by CDC27-low versus CDC27-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC27→partner) and Y-score (partner→CDC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EGFR_pY1173 →	+0.117	+3.321	.015	.010	3	2
SKCM	Myosin-IIa_pS1943 →	-0.318	-3.304	.029	.010	3	2
SKCM	S6_pS240_S244 →	-0.515	-2.982	.017	.034	3	2
UCEC	EGFR_pY1068 →	-0.251	-2.662	.002	<.001	3	2
UCEC	eIF4E →	+0.215	+1.874	.002	.002	3	2
UCEC	GAPDH →	+0.431	+2.700	.016	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

EGFR_pY1173 by CDC27 expression — SKCM

Explore this box plot interactively →