CDC27

Across TCGA cell cohorts, CDC27 mutation is significantly associated with the mutation status of many other genes, with 1,380 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDC27-associated genes across cancer lineages are GBP6, ZNF142, and SETD2. Each is linked with CDC27 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDC27-to-partner and partner-to-CDC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GBP6 grouped by CDC27-low versus CDC27-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC27→partner) and Y-score (partner→CDC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GBP6 →	+4.459	+5.277	.005	.005	1	4
BREAST	ZNF142 →	+5.297	+5.297	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	SETD2 →	+4.392	+4.954	.008	.008	1	3
BREAST	NOP9 →	+4.297	+4.857	.009	.009	1	3
UPPER_AERODIGESTIVE_TRACT	NUP160 →	+5.392	+5.392	.004	.004	1	3
BLOOD_Lymphoma	ZC3H7B →	+4.832	+4.832	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,380 associations by consensus.

GBP6 by CDC27 expression — CNS

Explore this box plot interactively →