CDC23

Across TCGA patient cohorts, CDC23 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC23-associated genes across cancer lineages are cIAP, C-Raf, and EGFR_pY1068. Each is linked with CDC23 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC23-to-partner and partner-to-CDC23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by CDC23-low versus CDC23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC23→partner) and Y-score (partner→CDC23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cIAP →	+0.127	+2.026	.040	.018	3	2
UCEC	C-Raf →	+0.259	+3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.314	-2.700	.005	.006	3	1
UCEC	EGFR →	-0.244	-2.000	<.001	.032	3	1
UCEC	A-Raf_pS299 →	-0.129	-3.000	.017	.036	3	1
UCEC	FoxM1 →	+0.300	+2.700	.010	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

cIAP by CDC23 expression — UCEC

Explore this box plot interactively →