CDC23

Across TCGA cell cohorts, CDC23 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,271 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDC23-associated GO terms across cancer lineages are Protein localization to chromosome, centromeric region, Protein import into nucleus, and Negative regulation of chromosome segregation. Each is linked with CDC23 in more than 16 cancer types. Because this analysis shows association rather than direction, both CDC23-to-partner and partner-to-CDC23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to chromosome, centromeric region grouped by CDC23-low versus CDC23-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC23→partner) and Y-score (partner→CDC23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Protein localization to chromosome, centromeric region →	+0.143	+0.805	<.001	<.001	3	17
LIVER	Protein import into nucleus →	+0.096	+0.902	<.001	<.001	3	17
PANCREAS	Negative regulation of chromosome segregation →	+0.123	+0.702	<.001	<.001	3	16
URINARY_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.080	+0.535	.004	.008	3	16
OESOPHAGUS	Regulation of mitotic sister chromatid segregation →	+0.173	+0.748	.001	.003	2	17
PANCREAS	Protein localization to kinetochore →	+0.156	+0.728	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,271 associations by consensus.

Protein localization to chromosome, centromeric region by CDC23 expression — PANCREAS

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