CDC20

Across TCGA patient cohorts, CDC20 mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC20-associated genes across cancer lineages are RNU6-799P, RNU1-49P, and TTTY2. Each is linked with CDC20 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC20-to-partner and partner-to-CDC20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-799P grouped by CDC20-low versus CDC20-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC20→partner) and Y-score (partner→CDC20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-799P →	+0.367	+5.435	<.001	.005	3	2
BRCA	RNU1-49P →	+0.189	+8.471	<.001	.005	3	2
BRCA	TTTY2 →	+0.014	+7.731	<.001	.009	3	2
KIRP	TCP11X1 →	+0.045	+5.928	<.001	.002	3	1
UCEC	INO80B-WBP1 →	+0.123	+3.577	<.001	.002	3	1
UCEC	RNA5SP414 →	+0.967	+2.769	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

RNU6-799P by CDC20 expression — HNSC

Explore this box plot interactively →