CDC20

Across TCGA patient cohorts, CDC20 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC20-associated genes across cancer lineages are Fibronectin, p62 Lck ligand, and VHL. Each is linked with CDC20 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC20-to-partner and partner-to-CDC20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by CDC20-low versus CDC20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC20→partner) and Y-score (partner→CDC20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.413	-2.990	.022	.036	3	1
UCEC	p62 Lck ligand →	+0.448	+3.169	.012	.020	3	1
UCEC	VHL →	-1.282	-3.169	<.001	.019	3	1
UCEC	Tuberin →	+0.430	+3.169	.003	.020	2	1
UCEC	Caspase-8 →	-0.341	-3.169	.013	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Fibronectin by CDC20 expression — UCEC

Explore this box plot interactively →