CDC16

Across TCGA patient cohorts, CDC16 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC16-associated genes across cancer lineages are MSH6, STAT3_pY705, and Tuberin_pT1462. Each is linked with CDC16 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC16-to-partner and partner-to-CDC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by CDC16-low versus CDC16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC16→partner) and Y-score (partner→CDC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.401	-3.459	.001	.005	3	2
UCEC	STAT3_pY705 →	-0.311	-2.105	.002	.017	3	2
UCEC	Tuberin_pT1462 →	+0.218	+1.584	.016	.036	3	2
UCEC	14-3-3_beta →	-0.081	-2.295	.039	.033	3	1
UCEC	Fibronectin →	-0.282	-1.797	.029	.025	3	1
UCEC	MEK1 →	+0.346	+2.584	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MSH6 by CDC16 expression — UCEC

Explore this box plot interactively →