CDC14B

Across TCGA patient cohorts, CDC14B mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC14B-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and TIGAR. Each is linked with CDC14B in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC14B-to-partner and partner-to-CDC14B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CDC14B-low versus CDC14B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC14B→partner) and Y-score (partner→CDC14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.164	-2.415	.006	.003	3	2
UCEC	Notch1 →	+0.126	+1.598	.013	.040	3	2
UCEC	TIGAR →	+0.121	+1.952	.027	.002	3	2
UCEC	ASNS →	+0.395	+1.807	.002	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.636	+2.341	.002	.003	3	2
UCEC	14-3-3_beta →	-0.091	-2.558	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

JNK_pT183_Y185 by CDC14B expression — UCEC

Explore this box plot interactively →