CDC123

Across TCGA patient cohorts, CDC123 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC123-associated genes across cancer lineages are MSH6, p62 Lck ligand, and PKC-a. Each is linked with CDC123 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC123-to-partner and partner-to-CDC123 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by CDC123-low versus CDC123-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC123→partner) and Y-score (partner→CDC123) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.407	-3.169	.008	.018	3	1
UCEC	p62 Lck ligand →	+0.334	+2.179	.027	.034	3	1
UCEC	PKC-a →	+0.375	+3.013	.047	.018	3	1
UCEC	S6_pS240_S244 →	+0.663	+2.820	<.001	.035	3	1
UCEC	Chk2 →	-0.221	-3.700	.043	.001	3	1
UCEC	STAT5a →	+0.470	+2.584	.011	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MSH6 by CDC123 expression — UCEC

Explore this box plot interactively →