CDC123

Across TCGA cell cohorts, CDC123 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,160 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CDC123-associated GO terms across cancer lineages are Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, DNA replication initiation, and Negative regulation of DNA-templated DNA replication. Each is linked with CDC123 in more than 13 cancer types. Because this analysis shows association rather than direction, both CDC123-to-partner and partner-to-CDC123 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by CDC123-low versus CDC123-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC123→partner) and Y-score (partner→CDC123) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.135	+0.868	.003	.001	3	14
BONE	DNA replication initiation →	+0.151	+0.537	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of DNA-templated DNA replication →	+0.125	+0.782	.001	.004	3	14
LUNG_SCLC	'de novo' cotranslational protein folding →	+0.166	+0.896	<.001	<.001	3	13
BONE	Mitochondrial RNA 3'-end processing →	+0.124	+0.659	.001	<.001	3	13
LUNG_SCLC	ATP generation from poly-ADP-D-ribose →	+0.107	+0.716	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,160 associations by consensus.

Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by CDC123 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →