CD8B2

Across TCGA pan-cancer cohorts, CD8B2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CD8B2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CD8B2 RNA is repressed in tumor relative to normal tissue. In most cancer types CD8B2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and BRCA are the cancer types where CD8B2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CD8B2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−1.238	<.001	9	view →
KICH	Female	II,III,IV	−1.681	<.001	7	view →
BRCA	Female	II,III,IV	−0.492	<.001	6	view →
BLCA	Male	All	−1.547	.015	5	view →
UCEC	All	All	+0.612	.014	2	view →
LUAD	All	IV	−0.570	.012	2	view →
LUSC	All	All	+0.490	.007	2	view →
KIRC	Female	IV	−0.830	.040	1	view →
LUSC	Male	III,IV	−0.235	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

CD8B2–KIRP

Open the KIRP breakdown →