CD8A

Across TCGA patient cohorts, CD8A protein abundance is significantly associated with the RNA expression of many other genes, with 11,327 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CD8A-associated genes across cancer lineages are CD79A, ITK, and CXCL9. Each is linked with CD8A in more than 9 cancer types. Because this analysis shows association rather than direction, both CD8A-to-partner and partner-to-CD8A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CD8A versus CD79A in BRCA, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD8A→partner) and Y-score (partner→CD8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD79A →	+1.908	+0.854	<.001	<.001	3	10
LSCC	ITK →	+1.199	+0.878	<.001	<.001	3	10
OV	CXCL9 →	+2.308	+0.856	<.001	<.001	3	10
LSCC	PYHIN1 →	+1.151	+0.895	<.001	<.001	3	10
HNSC	ZNF683 →	+0.995	+0.556	<.001	<.001	3	10
HNSC	TIGIT →	+1.245	+0.650	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,327 associations by consensus.

CD8A vs CD79A — BRCA

Explore this scatter interactively →