CD8A

Across TCGA patient cohorts, CD8A mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD8A-associated genes across cancer lineages are FoxM1, Caspase-8, and eIF4G. Each is linked with CD8A in more than 1 cancer types. Because this analysis shows association rather than direction, both CD8A-to-partner and partner-to-CD8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CD8A-low versus CD8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD8A→partner) and Y-score (partner→CD8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.290	+3.169	.041	.020	3	1
UCEC	Caspase-8 →	-0.367	-2.973	.007	.035	3	1
UCEC	eIF4G →	+0.348	+3.169	.041	.020	1	1
UCEC	Paxillin →	+0.430	+3.169	.002	.020	1	1
UCEC	PKC-delta_pS664 →	-0.153	-3.169	.020	.020	1	1
UCEC	Rab11 →	-0.161	-3.169	.043	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FoxM1 by CD8A expression — UCEC

Explore this box plot interactively →