CD8A

Across TCGA cell cohorts, CD8A mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CD8A-associated genes across cancer lineages are CD300H, FGF6, and OR2L5. Each is linked with CD8A in more than 1 cancer types. Because this analysis shows association rather than direction, both CD8A-to-partner and partner-to-CD8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300H grouped by CD8A-low versus CD8A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD8A→partner) and Y-score (partner→CD8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD300H →	+0.045	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	FGF6 →	+0.243	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.015	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C3 →	+0.018	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD300H by CD8A expression — LARGE_INTESTINE

Explore this box plot interactively →