CD8A

Across TCGA cell cohorts, CD8A mutation is significantly associated with the mutation status of many other genes, with 1,228 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD8A-associated genes across cancer lineages are MYSM1, SPECC1L, and PCDHB2. Each is linked with CD8A in more than 2 cancer types. Because this analysis shows association rather than direction, both CD8A-to-partner and partner-to-CD8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYSM1 grouped by CD8A-low versus CD8A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD8A→partner) and Y-score (partner→CD8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYSM1 →	+5.772	+5.772	.002	.002	1	3
LUNG_NSCLC_LUAD	SPECC1L →	+4.772	+5.339	.004	.004	1	2
LUNG_NSCLC_LUAD	PCDHB2 →	+4.187	+5.000	.008	.008	1	2
LUNG_NSCLC_LUAD	PARD3B →	+4.187	+5.000	.008	.008	1	2
LUNG_NSCLC_LUAD	RBPJL →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	ZSWIM4 →	+4.772	+5.339	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,228 associations by consensus.

MYSM1 by CD8A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →