CD86

Across TCGA patient cohorts, CD86 mutation is significantly associated with the RNA expression of many other genes, with 2,364 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD86-associated genes across cancer lineages are IFNWP4, CDH18-AS1, and BAG3. Each is linked with CD86 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD86-to-partner and partner-to-CD86 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNWP4 grouped by CD86-low versus CD86-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD86→partner) and Y-score (partner→CD86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IFNWP4 →	+0.093	+4.590	.004	.004	3	3
LUAD	CDH18-AS1 →	+0.293	+4.590	<.001	.004	3	3
UCEC	BAG3 →	+0.532	+2.415	.007	.003	3	2
UCEC	ZDHHC7 →	+0.430	+3.724	.002	<.001	3	2
UCEC	SEC13 →	+0.473	+3.087	<.001	<.001	3	2
UCEC	ZC3H18 →	+0.543	+2.930	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,364 associations by consensus.

IFNWP4 by CD86 expression — LUAD

Explore this box plot interactively →