CD86

Across TCGA cell cohorts, CD86 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,372 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD86-associated GO terms across cancer lineages are Regulation of lymphotoxin A production, Positive regulation of lymphotoxin A production, and L-histidine transport. Each is linked with CD86 in more than 8 cancer types. Because this analysis shows association rather than direction, both CD86-to-partner and partner-to-CD86 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of lymphotoxin A production grouped by CD86-low versus CD86-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD86→partner) and Y-score (partner→CD86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of lymphotoxin A production →	-0.941	-0.863	.003	.001	2	9
OESOPHAGUS	Positive regulation of lymphotoxin A production →	-0.941	-0.863	.003	.001	2	9
LUNG_NSCLC_LUSC	L-histidine transport →	+0.161	+0.307	<.001	.001	3	6
BLOOD_Leukemia	Astrocyte activation involved in immune response →	+0.159	+1.306	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Response to indole-3-methanol →	+0.139	+0.660	<.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	Desmosome organization →	+0.226	+0.677	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,372 associations by consensus.

Regulation of lymphotoxin A production by CD86 expression — OESOPHAGUS

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