CD86

Across TCGA cell cohorts, CD86 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CD86-associated genes across cancer lineages are GGTLC2, GABRR1, and TRIM50. Each is linked with CD86 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD86-to-partner and partner-to-CD86 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGTLC2 grouped by CD86-low versus CD86-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD86→partner) and Y-score (partner→CD86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GGTLC2 →	+0.024	+3.103	<.001	.004	3	1
SKIN	GABRR1 →	+0.205	+3.836	<.001	.003	3	1
SKIN	TRIM50 →	+0.066	+3.940	<.001	.002	3	1
SKIN	CA10 →	+0.211	+3.426	.002	.007	3	1
SKIN	LCN1 →	+0.297	+2.925	<.001	.007	3	1
SKIN	MMP26 →	+0.011	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GGTLC2 by CD86 expression — SKIN

Explore this box plot interactively →