CD83

Across TCGA patient cohorts, CD83 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD83-associated genes across cancer lineages are P-Cadherin, beta-Catenin, and MSH2. Each is linked with CD83 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD83-to-partner and partner-to-CD83 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-Cadherin grouped by CD83-low versus CD83-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD83→partner) and Y-score (partner→CD83) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	P-Cadherin →	-0.186	-3.308	.013	.010	3	1
UCEC	beta-Catenin →	+0.561	+3.321	.034	.010	3	1
UCEC	MSH2 →	-0.484	-2.990	<.001	.036	2	1
UCEC	p27 →	-0.298	-3.321	.009	.010	2	1
UCEC	PRAS40_pT246 →	+0.299	+3.169	<.001	.019	2	1
UCEC	4E-BP1 →	+0.408	+3.321	.004	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

P-Cadherin by CD83 expression — UCEC

Explore this box plot interactively →