CD80

Across TCGA patient cohorts, CD80 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD80-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with CD80 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD80-to-partner and partner-to-CD80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CD80-low versus CD80-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD80→partner) and Y-score (partner→CD80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.198	+3.459	.023	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.808	+2.019	<.001	.017	3	2
UCEC	4E-BP1 →	+0.405	+2.321	<.001	.006	3	2
UCEC	Cyclin-B1 →	+0.664	+3.169	.004	.018	3	2
UCEC	EGFR_pY1068 →	-0.240	-1.807	.020	.027	3	1
UCEC	ER-alpha_pS118 →	-0.347	-3.459	.019	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by CD80 expression — UCEC

Explore this box plot interactively →