CD80

Across TCGA cell cohorts, CD80 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,693 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD80-associated GO terms across cancer lineages are Host-mediated perturbation of viral process, Melanosome assembly, and Negative regulation of mRNA metabolic process. Each is linked with CD80 in more than 4 cancer types. Because this analysis shows association rather than direction, both CD80-to-partner and partner-to-CD80 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Host-mediated perturbation of viral process grouped by CD80-low versus CD80-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD80→partner) and Y-score (partner→CD80) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Host-mediated perturbation of viral process →	+0.072	+0.030	<.001	.007	3	5
SKIN	Melanosome assembly →	+0.094	+0.130	.001	.006	3	4
OVARY	Negative regulation of mRNA metabolic process →	+0.051	+0.076	.003	.007	3	4
OVARY	Fertilization →	-0.078	-0.074	<.001	<.001	3	4
LARGE_INTESTINE	Positive regulation of TORC2 signaling →	+0.048	+0.029	.006	.005	3	4
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.059	+0.050	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,693 associations by consensus.

Host-mediated perturbation of viral process by CD80 expression — UPPER_AERODIGESTIVE_TRACT

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