CD74

Across TCGA patient cohorts, CD74 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD74-associated genes across cancer lineages are Ku80, PCNA, and Caspase-7-cleavedD198. Each is linked with CD74 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD74-to-partner and partner-to-CD74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CD74-low versus CD74-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD74→partner) and Y-score (partner→CD74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.310	+3.183	.006	.009	3	1
UCEC	PCNA →	+0.272	+2.459	.009	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.866	+2.459	.002	.020	3	1
UCEC	Caspase-8 →	-0.248	-2.973	.041	.035	3	1
UCEC	4E-BP1 →	+0.339	+3.029	.009	.018	3	1
UCEC	Cyclin-B1 →	+0.694	+2.459	.010	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by CD74 expression — UCEC

Explore this box plot interactively →