CD74

Across TCGA cell cohorts, CD74 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD74-associated genes across cancer lineages are TMCO5A, AQP12A, and GSG1L2. Each is linked with CD74 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD74-to-partner and partner-to-CD74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by CD74-low versus CD74-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD74→partner) and Y-score (partner→CD74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
BLOOD_Leukemia	AQP12A →	+0.179	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TMCO5A by CD74 expression — LARGE_INTESTINE

Explore this box plot interactively →