CD74

Across TCGA cell cohorts, CD74 mutation is significantly associated with the mutation status of many other genes, with 2,768 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CD74-associated genes across cancer lineages are ELMO3, TLX1, and USP21. Each is linked with CD74 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD74-to-partner and partner-to-CD74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELMO3 grouped by CD74-low versus CD74-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD74→partner) and Y-score (partner→CD74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELMO3 →	+3.350	+4.584	.003	.003	1	3
BLOOD_Leukemia	TLX1 →	+4.560	+4.309	.007	.007	1	3
BLOOD_Leukemia	USP21 →	+3.560	+4.247	.002	.002	1	3
BLOOD_Leukemia	SLC39A1 →	+4.560	+4.309	.007	.007	1	3
LARGE_INTESTINE	MAML1 →	+3.087	+4.392	.005	.005	1	3
BLOOD_Leukemia	LMOD1 →	+5.560	+4.736	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,768 associations by consensus.

ELMO3 by CD74 expression — LARGE_INTESTINE

Explore this box plot interactively →