CD68

Across TCGA patient cohorts, CD68 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD68-associated genes across cancer lineages are eEF2, FOXO3a_pS318_S321, and INPP4B. Each is linked with CD68 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD68-to-partner and partner-to-CD68 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CD68-low versus CD68-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD68→partner) and Y-score (partner→CD68) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.537	+3.459	.002	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.163	-2.321	.009	.035	3	1
UCEC	INPP4B →	-0.385	-2.999	.017	.035	3	1
UCEC	p70-S6K_pT389 →	-0.239	-2.321	.012	.035	3	1
UCEC	PDCD4 →	-0.674	-3.160	.004	.019	3	1
UCEC	Annexin-1 →	+0.767	+2.827	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eEF2 by CD68 expression — UCEC

Explore this box plot interactively →