CD6

Across TCGA patient cohorts, CD6 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD6-associated genes across cancer lineages are S6, 4E-BP1, and eIF4E. Each is linked with CD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CD6-to-partner and partner-to-CD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6 grouped by CD6-low versus CD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD6→partner) and Y-score (partner→CD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6 →	-0.244	-1.678	.017	.023	3	3
UCEC	4E-BP1 →	+0.218	+2.999	.036	.035	3	3
UCEC	eIF4E →	+0.188	+3.013	.020	.018	3	1
UCEC	ERK2 →	+0.191	+1.678	.009	.023	3	1
UCEC	GAPDH →	+0.519	+2.584	.011	.010	3	1
UCEC	MEK1 →	+0.430	+2.584	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

S6 by CD6 expression — UCEC

Explore this box plot interactively →