CD6

Across TCGA cell cohorts, CD6 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CD6-associated genes across cancer lineages are DYTN, MS4A13, and OR4C12. Each is linked with CD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD6-to-partner and partner-to-CD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYTN grouped by CD6-low versus CD6-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD6→partner) and Y-score (partner→CD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DYTN →	+0.006	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	MT1HL1 →	+0.173	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR4M2 →	+0.267	+4.887	<.001	.009	3	1
BLOOD_Leukemia	BHLHE23 →	+1.778	+3.691	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

DYTN by CD6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →