CD6

Across TCGA cell cohorts, CD6 mutation is significantly associated with the mutation status of many other genes, with 3,449 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CD6-associated genes across cancer lineages are SLC27A1, HECW2, and CLSTN2. Each is linked with CD6 in more than 3 cancer types. Because this analysis shows association rather than direction, both CD6-to-partner and partner-to-CD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC27A1 grouped by CD6-low versus CD6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD6→partner) and Y-score (partner→CD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC27A1 →	+5.339	+4.772	.004	.004	1	4
LUNG_NSCLC_LUAD	HECW2 →	+4.339	+4.339	.009	.009	1	4
BLOOD_Leukemia	CLSTN2 →	+3.662	+3.285	.004	.004	1	4
LUNG_NSCLC_LUAD	PTPRU →	+3.339	+4.662	.003	.003	1	4
LARGE_INTESTINE	GRIN3B →	+2.152	+2.787	.005	.005	1	4
LARGE_INTESTINE	COL24A1 →	+2.415	+3.510	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,449 associations by consensus.

SLC27A1 by CD6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →