CD5L

Across TCGA pan-cancer cohorts, CD5L RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated CD5L data layer compared with 8 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CD5L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CD5L expression acts as an unfavorable survival marker, although some lineages such as LIHC and SKCM show a favorable association.

UVM, LIHC, and SKCM are the cancer types where CD5L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.369	0.858	<.001	140	view →
LIHC	OS	Tertile	All	0.615	0.407	<.001	75	view →
SKCM	OS	Tertile	All	0.864	0.725	<.001	47	view →
KIRC	DFS	Median	II,III,IV	0.615	0.440	.002	40	view →
UCS	OS	Tertile	IV	0.294	0.664	.012	36	view →
READ	DFS	Tertile	II,III,IV	0.187	0.744	<.001	24	view →
COAD	OS	Tertile	All	0.695	0.840	.013	23	view →
LUSC	OS	Quartile	All	0.665	0.874	.013	20	view →
LGG	OS	Tertile	All	0.740	0.865	.003	19	view →
OV	OS	Median	IV	0.268	0.458	.016	14	view →
ACC	DFS	Median	III,IV	0.123	0.570	.009	9	view →
SCLC	DFS	Median	III,IV	0.968	0.338	.024	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

CD5L–UVM (OS)

Open the UVM breakdown →