CD59

Across TCGA patient cohorts, CD59 mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CD59-associated genes across cancer lineages are LINC01338, RN7SKP221, and TRDD1. Each is linked with CD59 in more than 1 cancer types. Because this analysis shows association rather than direction, both CD59-to-partner and partner-to-CD59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01338 grouped by CD59-low versus CD59-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CD59→partner) and Y-score (partner→CD59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01338 →	+0.432	+2.993	<.001	.006	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1
UCEC	OR7C2 →	+0.253	+3.033	<.001	.004	3	1
UCEC	H3P42 →	+0.271	+3.646	.009	<.001	3	1
UCEC	RN7SKP290 →	+0.353	+3.621	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

LINC01338 by CD59 expression — UCEC

Explore this box plot interactively →