CD59

Across TCGA cell cohorts, CD59 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,110 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CD59-associated GO terms across cancer lineages are Positive regulation of cell-substrate adhesion, Viral life cycle, and Regulation of proteolysis. Each is linked with CD59 in more than 14 cancer types. Because this analysis shows association rather than direction, both CD59-to-partner and partner-to-CD59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate adhesion grouped by CD59-low versus CD59-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CD59→partner) and Y-score (partner→CD59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate adhesion →	+0.138	+2.154	<.001	<.001	3	15
BONE	Viral life cycle →	+0.078	+2.079	<.001	<.001	3	15
BONE	Regulation of proteolysis →	+0.105	+2.075	<.001	<.001	3	15
OESOPHAGUS	Substrate adhesion-dependent cell spreading →	+0.192	+1.467	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Wound healing →	+0.125	+1.673	.001	.006	3	15
BREAST	Symbiont entry into host →	+0.111	+1.307	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,110 associations by consensus.

Positive regulation of cell-substrate adhesion by CD59 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →